Brain chemistry is certainly important in depression but we don't know enough about it to rely on it for treatment. A large investigation was done into genomic

Brain chemistry is certainly important in depression but we don't know enough about it to rely on it for treatment. A large investigation was done into genomic links to depression and there were no markers related to serotonin / dopamine genes. SSRIs were discovered through serendipity largely and nothing new has really been developed since bc we don't know much about the brain (though we think NMDA receptor agonists and some allosteric modulators of GABA r may work) Therapy is the right way to handle a lot of depression cases, but very few people get it because of stigma and the fact that psychiatrists can't make money doing therapy unless the patients are rich