The standard OCaml native compile toolchain supports Reason: http://jbuilder.readthedocs.io/en/latest/overview.html?highlight=reason http://jbuilder.readthedocs

The standard OCaml native compile toolchain supports Reason: http://jbuilder.readthedocs.io/en/latest/overview.html?highlight=reason http://jbuilder.readthedocs.io/en/latest/overview.html?highl... You can write in Reason syntax and deploy native binaries with Docker: https://medium.com/@bobbypriambodo/lightweight-ocaml-docker-images-with-multi-stage-builds-f7a060c7fce4 https://medium.com/@bobbypriambodo/lightweight-ocaml-docker-... JS and native differences will probable be resolved just like with any other language that supports both: packages for common code, with specialised packages targeting specific platforms and having dependencies on the common packages.