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Gut Microbes Combine to Cause Colon Cancer, Study Suggests
- ValentineC 9y agoIt's scary that Bacteroides fragilis is being seen as some kind of "autism cure" [1], and some people actively seek out probiotics with it. [1] https://www.nature.com/news/bacterium-can-reverse-autism-like-behaviour-in-mice-1.14308 https://www.nature.com/news/bacterium-can-reverse-autism-lik...
- e40 9y agoYikes. Is this a common additive to probiotics?
- colordrops 9y agoIf the cancer risk is low enough and the treatment works it might be worth it. CT scans cause cancer too and yet people get them all the time.
- vesak 9y agoDo probiotics generally work against the bacteria mentioned in the article?
- giarc 9y agoYes but, having B fragilis doesn't mean you'll get cancer. So it's like any medical treatment, you weigh the risks against the benefits.
- TheAdamAndChe 9y agoHuh. The wikipedia page of bacteriodes fragilis says that it's an obligate anaerobe[1]. I thought that our bodies were filled circulating oxygen-rich fluids. How can obligate anaerobes surivive in our bodies? [1] https://en.wikipedia.org/wiki/Bacteroides_fragilis https://en.wikipedia.org/wiki/Bacteroides_fragilis
- yorwba 9y agoYour colon hopefully isn't filled with oxygen-rich fluids. And I'm pretty sure that most of the oxygen in blood is bound in red blood cells, so the bacteria would be pretty unlikely to be harmed by it.
- DoreenMichele 9y agohttps://www.ncbi.nlm.nih.gov/pubmed/3568965 https://www.ncbi.nlm.nih.gov/pubmed/3568965 Gangrene can be treated in part by using a hyperbaric chamber to increase oxygen content of the body. Presumably, if our tissues were all oxygenated, gangrene would never happen.
- Fomite 9y agoYour body is not a sack. There are different structures, with different oxygenation levels in them. Anaerobic bacteria do especially well in mucous-rich areas - the mouth, the gut, and the female genital tract.
- Jemmeh 9y agoBacteroides fragilis is part of normal gut flora[1]. It can cause infections in the bloodstream(like after surgery/from disease) but trying to balance it in the gut is a different issue entirely. The 2013 study did show some reduction in autism-like symptoms in mice. And they did another mice study on probiotic Lactobacillus reuteri in 2016 with reduction of autism-like symptoms as well. It's not a cure, but they are studying it to help symptoms. I'm fairly certain you can't buy B. Fragilis commercially anyways. https://www.autismspeaks.org/blog/2016/06/24/new-findings-probiotics-and-autism-what-you-need-know https://www.autismspeaks.org/blog/2016/06/24/new-findings-pr... [1] https://en.wikipedia.org/wiki/Gut_flora https://en.wikipedia.org/wiki/Gut_flora
- ainiriand 9y agoKind of related: https://www.youtube.com/watch?v=VzPD009qTN4 https://www.youtube.com/watch?v=VzPD009qTN4
- taeric 9y agoIt is kind of scary to see some of the "old guards" of the medical advice I grew up with getting basically tossed. In an exciting way, I should add. Ulcers, in particular, was huge. So much of previous advice for dealing with them was just flat out wrong. If this pans out, I'm very interested to see where it goes next.
- steamer25 9y agoCould you point out some of the updated advice on ulcers?
- cscheid 9y agohttps://www.nobelprize.org/nobel_prizes/medicine/laureates/2005/press.html https://www.nobelprize.org/nobel_prizes/medicine/laureates/2...
- taeric 9y agoThanks for giving that link. Highly recommend reading it for anyone. And, honestly, this makes me think I should be reading the announcements of all Nobel prizes now. Did a really good job summarizing the reasons.
- Onewildgamer 9y agoIs there any cure for it apart from the restricted use of antibiotics?
- taeric 9y agoI don't actually know. :( My understanding would think diet change could work. But only if you manage to starve the bacteria. Anti biotics are much more straight forward and effective here. Obviously finish your dose. That said, I've never had an ulcer, so have not actually read much. Other than finding it was none of the root causes I heard growing up.
- huy-nguyen 9y agoThis is very interesting. It looks like a few subtypes of colon cancers may join the list of cancers caused by bacteria (H. pylori in stomach cancer) or virus (HPV in cervical cancer, Hepatitis in liver cancer). Every bit of preventive care against cancer helps and hopefully a vaccine against these bacteria can save many lives in the future.
- jvkersch 9y agoInterestingly, there is some push-back against treating H. pylori too aggressively. While it is linked to stomach cancer, there is also some evidence that losing H. pylori is linked with increases in other diseases like type-2 diabetes (but then again, increased rates of type-2 diabetes are linked to losing pretty much any kind of stomach/gut flora). The microbiome is a delicate thing...
- ams6110 9y agoIs there such a thing as a vaccine against a bacteria? I thought vaccines were for viral infections.
- openasocket 9y agoThere very much are! For example, Diptheria, Pertussis, and Tetanus are all caused by bacteria, and we have vaccines for all three
- refurb 9y agoThe interesting things about diptheria and tetanus is that the vaccine is not targeted against the bacteria, but rather the toxin they produce. If you've been vaccination against both of these diseases and are exposed, your immune system will eventually mount an attack against the bacteria, but already has antibodies floating around that inactivate the toxin, which is what is responsible for the severity of the diseases.
- dvfjsdhgfv 9y agoProbably the most popular of these are against pneumococcal bacteria (Prevnar, Pneumovax...).
- DoreenMichele 9y agoTwo types of bacteria, Bacteroides fragilis and a strain of E. coli, can pierce a mucus shield that lines the colon and normally blocks invaders from entering The above text in the article contains a link to an abstract. The abstract does not talk about piercing the mucus lining. It talks about biofilm. Biofilm is essentially a large colony of bacteria, so large it begins terraforming the body in order to create conditions conducive to self preservation. I have seen a number of articles over the years on how to successfully break up biofilm and thereby reverse antibiotic resistance. They generally boil down to finding some means to make the environment less acidic. There is generally a strong correlation between inflammation, acidity and infection. This is probably not a simple relationship. The terraforming activities of biofilm suggests bacteria will foster acidity to promote inflammation etc. So the relationship is interactive. It is not as simple as "acidity causes antibiotic resistance". I don't have these studies at my fingertips. I have no plans to try to dig them up. I am leaving the comment so that other people can look into that if they are interested. I wasn't reading this stuff in order to support debate points in an online forum. I have a genetic disorder that predisposes me to developing antibiotic resistant infections and I was trying to suffer less. So, you can take this comment as testimony that these studies exist and may have bearing on the topic of discussion here. But I am not going to debate this with people who are inevitably monstrously disrespectful towards me and who act like the last 17 years of my life did not happen because I can't link you to a study. The reality is they don't get any less monstrously disrespectful when I do link to studies and supporting articles and explain my thinking etc. So I don't plan to play that game today. TLDR: If you are interested, you might go looking up studies on how to break up biofilm. They do exist and they contain potentially useful clues to how to stop this kind of colonization of the gut by hostile invaders.
- epmaybe 9y agoI have always been taught that antibiotic resistance came from bacterial mutation. Are you suggesting that this biofilm is contributing to this resistance as well or instead of mutation?
- DoreenMichele 9y agoMy dad fought in WW2. He used to tell this story: First, invaders would toss a grenade into a room, stunning all occupants, then promptly rush in and capture them at gun point. Then people began creating a safety zone in the corner with sand bags. When the grenade hit the floor, you dive for cover. After it goes off, you stand up with your weapon, getting the upper hand on the soldiers entering the room. Then they began tossing the grenade without pulling the pin. People dove for cover and waited for the grenade to go off. Meanwhile, you promptly enter and now you have the jump on them. So then people would hear the grenade hit the floor and look to see if the pin had been pulled before deciding how to react. When antibiotics were introduced, the world announced the end of disease. Now, we have antibiotic resistant super bugs. Antibiotic resistance is an arms race. It is probably not one dimensional. If infectious process were one dimensional, then the initial prediction that antibiotics heralded the ended of disease should have been accurate. But the only thing I am trying to suggest is that studies exist and people who are interested can look them up for themselves, read them and draw their own conclusions. I am sick to death of trying to discuss what I think about such things. It is never a positive experience.
- bengalister 9y agoI am wondering if the type of bacteria they mention is the one that can be found in probiotics. I think I suffer from intestinal candida (I have many of the symptoms) and medical exams of my intestine did not reveal anything (Helicobacter Pylori had been tested but not candida). Thus I have reduced drastically my carbs consumption and also take some probiotics to well balance the yeast/bacteria ratio in my gut.
- blacksmith_tb 9y agoI haven't seen B. fragilis in any OTC probiotic supplement, but wouldn't hurt to check the label. Typically manufacturers choose strains which are well-studied enough to be blameless, if not necessarily magically good for you (to avoid liability, the cynic in me says...)
- arkades 9y agoProbiotics are typically various strains of lactobacillus. Although E. coli and B. fragilis are “commensal flora,” they can be extraordinarily pathogenic. I don’t think any company wants to take on the liability of feeding you a bacteria with a ~20% mortality rate (the BF) and trying to ensure their cultures never get contaminated with a more toxogenic strain -and- that no one takes it the wrong way (oh, did you bite that capsule open and get the B. fragilis into your peptic ulcer...?).
- sharpshadow 9y agoWhat do these microbes feed on?
- grzm 9y agoThe same stuff we do. They consume what we eat. And each other, and the byproducts of each other. We (the human) consume these latter to greater and lesser degrees as well.
- marz0 9y agoThey eat certain carbohydrates (such as fiber) [0] that we consume and aren't able to digest by ourselves. This is why it's recommended to eat fiber [1], which many people do not eat enough of. [2] [0] https://en.wikipedia.org/wiki/Gut_flora#Metabolism https://en.wikipedia.org/wiki/Gut_flora#Metabolism [1] https://www.sciencedaily.com/releases/2016/11/161117134626.htm https://www.sciencedaily.com/releases/2016/11/161117134626.h... [2] https://www.webmd.com/diet/guide/fiber-how-much-do-you-need#1 https://www.webmd.com/diet/guide/fiber-how-much-do-you-need#...
- agitator 9y agoWhat I'd like to know is which types of diets either inhibit/promote the growth of these bad bacteria. The types of bacteria in your gut being linked to parents or young age, might just be a symptom of learning your diet from your parents.
- acct1771 9y agoAnecdotal evidence from someone who's been through some of the worst digestive issues possible (stops in involuntary peristalsis/motility, food not digesting) due to "bad" bacteria being continuously introduced from infection elsewhere: yogurt. Specifically kefir/filmjölk. Buy a bottle, take a serving in the morning, and at night if you like/can afford. I've turned my life around. Friends have stopped proton pump inhibitors/antacids like Prilosec/Omeprezole, etc, because of this simple lifestyle switch (one serving per day). I take many more.
- acct1771 9y agoAlso, foods with digestive fiber feed good bacteria, and stop them from munching on YOU, aka, gut inflammation, which is also a big thing we're somehow just learning about now, with relation to how it can ruin your entire life (no exaggeration) with stuff like cancers, Alzheimer's, Parkinson's most likely, etc.
- Onewildgamer 9y agoWould like to hear more about how the change in your lifestyle and food habits made a difference. If you don't mind sharing, you can email me, my email id's in my profile.
- lbenes 9y ago> the morning, and at night if you like/can afford. If you have an instapot or yogurt maker, for $2.5, you can make a gallon of yogurt which lasts me about 1-2 weeks. I started my culture with a tub of Activia that my sister left in the fridge ~ a year ago. Kimchi is also cheap to make yourself, although it does take a bit more prep.
- 2_listerine_pls 9y agoIf anyone is interested about the topic, there is an introductory MOOC from Wageningen University about the intestinal microbiome and it's effects on health. https://www.edx.org/course/nutrition-health-human-microbiome-wageningenx-nutr104x https://www.edx.org/course/nutrition-health-human-microbiome...
- aoner 9y agoTangentially related, when implants are placed there is a so called "race to surface" where bacteria try to form a biofilm before the immune system can react properly. Quote: After adhering to the surface, the bacterium starts to divide and encapsulate itself for protection against the host organism’s immune response. This layer of protective matrix, mostly consisting out of polysaccharides, also shields the bacteria from effective antibiotic treatment. The first stage of the biofilm formation is complete and subsequently the present bacteria start to form colonies increasing the internal pressure in the biofilm, which starts to expand. https://www.researchgate.net/figure/259382333_Figure-1-A-schematic-representation-of-the-race-for-the-surface-between-the-bacterial-biofilm-co https://www.researchgate.net/figure/259382333_Figure-1-A-sch...
- car 9y agoSince this study found biofilms in colon cancer, I'd like to point out this recent discovery on the involvement of bacterial phage in biofilm formation: https://biox.stanford.edu/highlight/dangerous-liaison-bacteria-viruses-league https://biox.stanford.edu/highlight/dangerous-liaison-bacter...
- dghughes 9y agoIf you do develop colon cancer and are treated with certain chemo drugs some types of bacteria may be eating the drug. http://science.sciencemag.org/content/357/6356/1156 http://science.sciencemag.org/content/357/6356/1156
- Pica_soO 9y agoMaybe the interesting question is what allows for the mucus lining of the intestines walls to deteriorate that much, that those strain of bacteria settle in.