Is there any modern webmail client that's secure and easy to set up? I know about Squirrel Mail and there was another one using the Horde framework, but I'd rat

Is there any modern webmail client that's secure and easy to set up? I know about Squirrel Mail and there was another one using the Horde framework, but I'd rather use a uwSGI/PSGI app that preferably doesn't need a mySQL database.