3 ms·

Black pepper increases bioavailability of everything by inhibiting your cytochrome p450 enzymes, which increases your vulnerability to toxins.

• IAmGraydon 9y ago
  There’s a difference between bioavailability and half life. Metabolic enzyme inhibition increases half life due to decreased hepatic metabolism of certain drugs. Bioavailability is how much of a drug your body absorbs from the initial dose. Also, black pepper inhibits CYP3A4, not 450.
  • nwah1 9y ago
    There is a difference, but increasing either the bioavailability or half life of toxins is undesirable. Also, CYP3A4 is one of the p450 enzymes. But after looking it up, piperine does seem to be specific to CYP3A4, which is better than inhibiting p450 in general.
  • nwah1 9y ago
    Interestingly, it seems that curcuminoids themselves also inhibit p450, with less specificity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574793/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574793/ And p450 exists in the brain, which may relate to the OP suggestion that turmeric boosts memory, but doesn't give me confidence that it boosts it in a way that is absent of tradeoffs. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223320/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223320/