6 ms·

For those commenting on bioavailability, black pepper supposedly makes it more bioavailable: https://examine.com/supplements/curcumin/ https://examine.com/supp

For those commenting on bioavailability, black pepper supposedly makes it more bioavailable: https://examine.com/supplements/curcumin/ https://examine.com/supplements/curcumin/ It's an interesting result, but they do note that the subpopulation is somewhat self-selected: "Only approximately 15% of the screened volunteers were included in the study, and our recruitment method yielded a sample of motivated, educated, physically healthy subjects concerned about age-related memory problems. The sample, therefore, was not representative of the general population. "

flipp3r 9y ago
Very interesting to see this posted. In Japan its ingredients are used in an anti-hangover drink, this youtube video https://youtu.be/Ij_aJI5O9Rs https://youtu.be/Ij_aJI5O9Rs goes somewhat deeper into it, where the poster tried a combination of it and pepper to strengthen the effect.
- mtgx 9y ago
  Speaking of Japan, I recently saw an interesting video about why Japanese people are so thin, compared to say the US: https://www.youtube.com/watch?v=lr4MmmWQtZM https://www.youtube.com/watch?v=lr4MmmWQtZM
  - flipp3r 9y ago
    Yeah, that's from the same channel :)
nwah1 9y ago
Black pepper increases bioavailability of everything by inhibiting your cytochrome p450 enzymes, which increases your vulnerability to toxins.
- IAmGraydon 9y ago
  There’s a difference between bioavailability and half life. Metabolic enzyme inhibition increases half life due to decreased hepatic metabolism of certain drugs. Bioavailability is how much of a drug your body absorbs from the initial dose. Also, black pepper inhibits CYP3A4, not 450.
  - nwah1 9y ago
    There is a difference, but increasing either the bioavailability or half life of toxins is undesirable. Also, CYP3A4 is one of the p450 enzymes. But after looking it up, piperine does seem to be specific to CYP3A4, which is better than inhibiting p450 in general.
  - nwah1 9y ago
    Interestingly, it seems that curcuminoids themselves also inhibit p450, with less specificity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574793/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574793/ And p450 exists in the brain, which may relate to the OP suggestion that turmeric boosts memory, but doesn't give me confidence that it boosts it in a way that is absent of tradeoffs. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223320/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223320/

flipp3r 9y ago

Very interesting to see this posted. In Japan its ingredients are used in an anti-hangover drink, this youtube video https://youtu.be/Ij_aJI5O9Rs https://youtu.be/Ij_aJI5O9Rs goes somewhat deeper into it, where the poster tried a combination of it and pepper to strengthen the effect.

mtgx 9y ago
Speaking of Japan, I recently saw an interesting video about why Japanese people are so thin, compared to say the US: https://www.youtube.com/watch?v=lr4MmmWQtZM https://www.youtube.com/watch?v=lr4MmmWQtZM
- flipp3r 9y ago
  Yeah, that's from the same channel :)

nwah1 9y ago

Black pepper increases bioavailability of everything by inhibiting your cytochrome p450 enzymes, which increases your vulnerability to toxins.

IAmGraydon 9y ago
There’s a difference between bioavailability and half life. Metabolic enzyme inhibition increases half life due to decreased hepatic metabolism of certain drugs. Bioavailability is how much of a drug your body absorbs from the initial dose. Also, black pepper inhibits CYP3A4, not 450.
- nwah1 9y ago
  There is a difference, but increasing either the bioavailability or half life of toxins is undesirable. Also, CYP3A4 is one of the p450 enzymes. But after looking it up, piperine does seem to be specific to CYP3A4, which is better than inhibiting p450 in general.
- nwah1 9y ago
  Interestingly, it seems that curcuminoids themselves also inhibit p450, with less specificity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574793/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574793/ And p450 exists in the brain, which may relate to the OP suggestion that turmeric boosts memory, but doesn't give me confidence that it boosts it in a way that is absent of tradeoffs. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223320/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223320/