Apart from checking the feasibility of the proposition I could imagine a few factors: - For evolution to occur in this directed way there should be some natura

Apart from checking the feasibility of the proposition I could imagine a few factors: - For evolution to occur in this directed way there should be some natural selection mechanism present. If the pathogen is able to reproduce and spread then it is fit, even if its genetic code is in a 'corrupt' state. - Even if there was some mechanism present, there still would be some generations apart for the fluctuation to smooth, so if the objective was a short term goal it would be successful.