I've read up a bit on the research, and it sounds like a next-day or 48-hour "blues period" is par for the course after an MDMA session. They mitigate this prob

I've read up a bit on the research, and it sounds like a next-day or 48-hour "blues period" is par for the course after an MDMA session. They mitigate this problem by making sure that your schedule is clear of obligations the next day and warning the patient about it ahead of time. The impact of MDMA in these trials is that it's not "a few hours of excitement": the drug often helps the patient make large, permanent breakthroughs in their trauma or self-image that wouldn't be possible without the "life preserver" of the substance. Going through the trauma and reorienting oneself to it in a new, healthy way seems much more possible (to many people anyway, certainly those with full-on diagnosable PTSD) with the help of MDMA.