4 ms·

Usually MDMA has the backlash of lowering the amount of serotonin release in your brain the days after you take it, which makes you feel down. The so-called tue

by kabes 9y ago

Usually MDMA has the backlash of lowering the amount of serotonin release in your brain the days after you take it, which makes you feel down. The so-called tuesday blues. So how come these people in these treatments aren't getting more depressed after their few hours of excitement?

triangleman 9y ago
Perhaps they are. The question is whether these treatments (combined with talk therapy) lead to positive long-term mental health outcomes.
09bjb 9y ago
I've read up a bit on the research, and it sounds like a next-day or 48-hour "blues period" is par for the course after an MDMA session. They mitigate this problem by making sure that your schedule is clear of obligations the next day and warning the patient about it ahead of time. The impact of MDMA in these trials is that it's not "a few hours of excitement": the drug often helps the patient make large, permanent breakthroughs in their trauma or self-image that wouldn't be possible without the "life preserver" of the substance. Going through the trauma and reorienting oneself to it in a new, healthy way seems much more possible (to many people anyway, certainly those with full-on diagnosable PTSD) with the help of MDMA.
deleted 9y ago
[deleted]
qwerty456127 9y ago
> Usually MDMA has the backlash of lowering the amount of serotonin release in your brain the days after you take it, which makes you feel down. The so-called tuesday blues Usually MDMA has absolutely no observable backlash (it may still harm your brain though, even if you don't feel it, I don't know if it will or not) if you don't take it more often than once in 3 months (or 1 month if you insist, but absolutely never more often), avoid taking too much of it, take enough piracetam, magnesium and antioxidants (acetyl-l-carnitine, acetyl-l-cysteine, vitamins E and C, lipoic acid, CoQ10, green tea extract, grape seed extract etc) before, during and after the MDMA trip, take L-tryptophan+piracetam after the trip, smoke some weed (but don't do it in advance - this can cause a panic attack and nausea), drink enough water, sleep well and take L-tryptophan+piracetam again when you get up. What will follow is usually going to be a rather pleasant state called "afterglow". Taking emoxypine, piracetam, magnesium and St. John's wort during the days after to actually restore the receptors can also be a good idea. I have also heard eating some psilocybin shrooms can prevent MDMA hangover too but I doubt combining psychedelics is a good idea for everybody. DISCLAIMER: The above is a piece of theoretical knowledge provided for harm-reduction purposes only and not even proven scientifically (I'd be glad if the researchers could consider checking it). Use it at your own risk. Don't take what is not legal in your country. I don't recommend taking MDMA without a prescription though I do recommend to consider harm-reduction measures if you decide to take it. Anyway, make sure you are not allergic to any of the substances you are going to take, are not taking any drugs that may interact with them and don't have any other contraindications.
- qwerty456127 9y ago
  Here is the source of the most of this knowledge by the way: https://www.youtube.com/watch?v=FlMxTpONKT0 https://www.youtube.com/watch?v=FlMxTpONKT0 Adam at PsychedSubstance does pretty good job educating people about how to do the stuff right without getting your brains fried. His advices do work great, it would surely be awesome if the reserachers could validate and/or improve them scientifically (or at least make use of them practically so nobody will actually get sad or experience any other adverse effects anyway).
  - _acme 9y ago
    How would you know that his advices (sic) work "great" without any research?
    - qwerty456127 9y ago
      The only problem with MDMA is it is not legal in the majority of countries. Up to hundreds thousands (something less maybe, but still a lot) of people all over the world would gladly submit reports about their experiences of taking MDMA together with and without these substances (piracetam, magnesium, antioxidants etc) if this was not associated with risk of getting busted by the authorities. I have no doubt his advices would have been proven statistically then.
- kabes 9y ago
  You kind of contradict yourself by saying there is no backlash and then giving a list of supplements to reduce the backlash... It's proven that your brain down-regulates serotonin after taking MDMA, which can last a couple of days (or even longer). What's not proven is those supplements you mention. They are the go-to advice you find on websites like rollsafe etc. but that's all based on shaky science (small control groups, non peer-reviewed papers, tests on mice that might not reflect on humans etc.). Basically MDMA has not been researched well enough on humans (so thanks Pineapple fund for improving this situation). There's also no evidence that supports 'afterglow' and the supplements you mention are mainly antioxidants (and magnesium to reduce jaw clenching) that will reduce the oxidation in the brain, but doesn't affect the serotonin levels. Another good way to reduce oxidation is to keep your body cooled (but hard to do at parties). Taking 5-HTP the days after might have an effect on serotonin levels, but again, research is lacking.

by kabes 9y ago

triangleman 9y ago

Perhaps they are. The question is whether these treatments (combined with talk therapy) lead to positive long-term mental health outcomes.

09bjb 9y ago

I've read up a bit on the research, and it sounds like a next-day or 48-hour "blues period" is par for the course after an MDMA session. They mitigate this problem by making sure that your schedule is clear of obligations the next day and warning the patient about it ahead of time. The impact of MDMA in these trials is that it's not "a few hours of excitement": the drug often helps the patient make large, permanent breakthroughs in their trauma or self-image that wouldn't be possible without the "life preserver" of the substance. Going through the trauma and reorienting oneself to it in a new, healthy way seems much more possible (to many people anyway, certainly those with full-on diagnosable PTSD) with the help of MDMA.

deleted 9y ago

[deleted]

qwerty456127 9y ago

> Usually MDMA has the backlash of lowering the amount of serotonin release in your brain the days after you take it, which makes you feel down. The so-called tuesday blues Usually MDMA has absolutely no observable backlash (it may still harm your brain though, even if you don't feel it, I don't know if it will or not) if you don't take it more often than once in 3 months (or 1 month if you insist, but absolutely never more often), avoid taking too much of it, take enough piracetam, magnesium and antioxidants (acetyl-l-carnitine, acetyl-l-cysteine, vitamins E and C, lipoic acid, CoQ10, green tea extract, grape seed extract etc) before, during and after the MDMA trip, take L-tryptophan+piracetam after the trip, smoke some weed (but don't do it in advance - this can cause a panic attack and nausea), drink enough water, sleep well and take L-tryptophan+piracetam again when you get up. What will follow is usually going to be a rather pleasant state called "afterglow". Taking emoxypine, piracetam, magnesium and St. John's wort during the days after to actually restore the receptors can also be a good idea. I have also heard eating some psilocybin shrooms can prevent MDMA hangover too but I doubt combining psychedelics is a good idea for everybody. DISCLAIMER: The above is a piece of theoretical knowledge provided for harm-reduction purposes only and not even proven scientifically (I'd be glad if the researchers could consider checking it). Use it at your own risk. Don't take what is not legal in your country. I don't recommend taking MDMA without a prescription though I do recommend to consider harm-reduction measures if you decide to take it. Anyway, make sure you are not allergic to any of the substances you are going to take, are not taking any drugs that may interact with them and don't have any other contraindications.

qwerty456127 9y ago
Here is the source of the most of this knowledge by the way: https://www.youtube.com/watch?v=FlMxTpONKT0 https://www.youtube.com/watch?v=FlMxTpONKT0 Adam at PsychedSubstance does pretty good job educating people about how to do the stuff right without getting your brains fried. His advices do work great, it would surely be awesome if the reserachers could validate and/or improve them scientifically (or at least make use of them practically so nobody will actually get sad or experience any other adverse effects anyway).
- _acme 9y ago
  How would you know that his advices (sic) work "great" without any research?
  - qwerty456127 9y ago
    The only problem with MDMA is it is not legal in the majority of countries. Up to hundreds thousands (something less maybe, but still a lot) of people all over the world would gladly submit reports about their experiences of taking MDMA together with and without these substances (piracetam, magnesium, antioxidants etc) if this was not associated with risk of getting busted by the authorities. I have no doubt his advices would have been proven statistically then.
kabes 9y ago
You kind of contradict yourself by saying there is no backlash and then giving a list of supplements to reduce the backlash... It's proven that your brain down-regulates serotonin after taking MDMA, which can last a couple of days (or even longer). What's not proven is those supplements you mention. They are the go-to advice you find on websites like rollsafe etc. but that's all based on shaky science (small control groups, non peer-reviewed papers, tests on mice that might not reflect on humans etc.). Basically MDMA has not been researched well enough on humans (so thanks Pineapple fund for improving this situation). There's also no evidence that supports 'afterglow' and the supplements you mention are mainly antioxidants (and magnesium to reduce jaw clenching) that will reduce the oxidation in the brain, but doesn't affect the serotonin levels. Another good way to reduce oxidation is to keep your body cooled (but hard to do at parties). Taking 5-HTP the days after might have an effect on serotonin levels, but again, research is lacking.