Tylenol definitely accrues liver damage over time. And your nephrologist is correct about NSAIDs. One of their direct effects is to reduce afferent blood flow

Tylenol definitely accrues liver damage over time. And your nephrologist is correct about NSAIDs. One of their direct effects is to reduce afferent blood flow to the kidney. Every time you take one you’re telling your kidney, “that amount of blood you think you need? Have a little less.” Blood flow to the kidney is extremely carefully regulated - this is never a good thing.