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I've had two doctors suggest taking over 2000mg a day like it was nothing. One of them was a fellow hiker on the Appalachian Trail and suggested it as a daily r
by marcoperaza 9y ago
I've had two doctors suggest taking over 2000mg a day like it was nothing. One of them was a fellow hiker on the Appalachian Trail and suggested it as a daily regimen for regular joint pain (common for long-distance hikers). The other suggested it for aiding recovery from mild frostnip. (In both cases, I ended up only taking it for a few days.)
Unless you have stomach problems—NSAIDs are linked to ulcers—high doses of ibuprofen have not been thought of as terribly risky.
- hesdeadjim 9y agoA nephrologist I went to a year or two ago explained to me that the danger of ibuprofen is total lifetime consumption. Once you approach 9lbs or so (surprisingly easy to hit if your habit is daily) your risk of kidney failure increases exponentially.
- marcoperaza 9y agoInteresting. I guess that's consistent with those doctors' advice since in both cases it suggested for a limited period, a few months and a few days.
- miguelrochefort 9y agoThat's roughly one pill a day for 50 years.
- pkaye 9y agoMy nephrologists all say NSAIDs on long term use have a risk for acute kidney failure. They say Tylenol is safe in long term as long as liver is otherwise healthy and you stay under daily dosage limit.
- wnoise 9y agoYeah, Tylenol damages the liver instead.
- arkades 9y agoTylenol definitely accrues liver damage over time. And your nephrologist is correct about NSAIDs. One of their direct effects is to reduce afferent blood flow to the kidney. Every time you take one you’re telling your kidney, “that amount of blood you think you need? Have a little less.” Blood flow to the kidney is extremely carefully regulated - this is never a good thing.