4 ms·

Yeah, I have to say "Common drug X has negative side effects after sustained daily exposure to high dosages" is hardly surprising. The study says participants w

Yeah, I have to say "Common drug X has negative side effects after sustained daily exposure to high dosages" is hardly surprising. The study says participants were given 1200mg per day for six weeks. For reference, a typical ibuprofen capsule in the US is 200mg. I'm sure this result is useful for the medical community or men specifically dealing with hypogonadism, but it doesn't seem to have a great deal of relevance to the average consumer who uses ibuprofen for occasional pain relief.

6nf 9y ago
1200mg is only 2 capsules 3 times per day, less than the maximum recommended for over the counter use. However any pharmacist would tell you not to use it for more than a few days in a row without seeing a doctor.
gknoy 9y ago
> 1200mg per day for six weeks. For reference, a typical ibuprofen capsule in the US is 200mg. Most people take 1-2 capsules (400mg), and the dosage documentation says no more than 8 per day (1600mg). The study seems to demonstrate people using the drug well within its over-the-counter maximum dosage. (When I tore up my knee as a teenager, my doctor prescribed it at about double that rate.)
- cookiecaper 9y ago
  If your doctor gives an Rx, they acknowledge that they're making a tradeoff and that it's the most applicable one for your overall health. I'm sure studies like this are helpful information for making such decisions, but this definitely doesn't seem to mean "taking ibuprofen will make you infertile". For what it's worth, I've also been Rx'd large ibuprofen dosages for a period of weeks at various times, and I've had six mostly-non-defective kids so far. I don't think this study warrants any type of generalized panic...
  - Devagamster 9y ago
    I think I understand what you're saying, but anecdotal evidence isn't really the point here. The article is pointing toward a societal trend, not one that is likely to be observed on a case by case basis. That said I do agree. All medications are a trade off of some sort. Usually the consequences aren't as bad as the effects of the drug, and I think this is no exception.

6nf 9y ago

1200mg is only 2 capsules 3 times per day, less than the maximum recommended for over the counter use. However any pharmacist would tell you not to use it for more than a few days in a row without seeing a doctor.

gknoy 9y ago

> 1200mg per day for six weeks. For reference, a typical ibuprofen capsule in the US is 200mg. Most people take 1-2 capsules (400mg), and the dosage documentation says no more than 8 per day (1600mg). The study seems to demonstrate people using the drug well within its over-the-counter maximum dosage. (When I tore up my knee as a teenager, my doctor prescribed it at about double that rate.)

cookiecaper 9y ago
If your doctor gives an Rx, they acknowledge that they're making a tradeoff and that it's the most applicable one for your overall health. I'm sure studies like this are helpful information for making such decisions, but this definitely doesn't seem to mean "taking ibuprofen will make you infertile". For what it's worth, I've also been Rx'd large ibuprofen dosages for a period of weeks at various times, and I've had six mostly-non-defective kids so far. I don't think this study warrants any type of generalized panic...
- Devagamster 9y ago
  I think I understand what you're saying, but anecdotal evidence isn't really the point here. The article is pointing toward a societal trend, not one that is likely to be observed on a case by case basis. That said I do agree. All medications are a trade off of some sort. Usually the consequences aren't as bad as the effects of the drug, and I think this is no exception.