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I mostly agree with that, with the caveat that it could... The part where it doesn't: AAVs do not integrate their DNA into the host genome, not by themselves a
by Amygaz 9y ago
I mostly agree with that, with the caveat that it could...
The part where it doesn't: AAVs do not integrate their DNA into the host genome, not by themselves at least. They form latent infections, which will persist until the cell divides or die.
However, the part where they could: AAVs can infect any type of cells, including germline cells. While they persist, if the cell becomes infected with an Adeno or Herpes virus, which can also infect a broad range of cells, then they could integrate into the host genome, including germline cells.