9 ms·

I've never really had a problem with opiods. I've gotten prescriptions for oxycodone a number of times. The only time I had any problem was when I broke my ha

I've never really had a problem with opiods. I've gotten prescriptions for oxycodone a number of times. The only time I had any problem was when I broke my hand in 2 places, and they gave me a 2 months supply (filled twice, not all at once) of 10mg. I had some of the standard opiod side effects, but no withdrawal or addictive behavior. I actually just had a prescription this year for a car accident, and did not find myself compulsively taking them or anything like that. On the other hand, I don't find they help me as much as others seem to be helped by them in terms of pain killing properties. I wonder why this is?

Bartweiss 9y ago
I've had a similar experience; a mild dose of oxycodone had no high, no withdrawal, and unremarkable pain relief. Individual variability is pretty high with opioids, both in efficacy and in metabolism speed. It's more pronounced with things like tramadol, but also true of oxycodone. At a guess, you might just be seeing much less impact from a given dose than other patients (and likely addicts might well be seeing more).
wastewaste 9y ago
because of renewed formular? I'm no pharmacist nor chemist, but my impression with drugs is that the popular names and actual composition are two different things. All they need is approval and if it helps relieve or avoid addiction I'm sure a minor change in, I don't know, isomery or adding a tiny functional extra tail to a big molecule doesn't preclude approval.
- rjbwork 9y ago
  It was generic Oxycodone. No name brand, no fancy time release, in both aforementioned cases. The first being in 2011.
xkcd-sucks 9y ago
Because addiction is an empirical behavioral phenomenon (you can't stop taking it and it makes your life worse) whereas tolerance+withdrawal are physical phenomena that correlate with, but are not, addiction. Current understanding is basically "addiction means not having your shit together," described in terms of predisposing factors such as stress, depression, physical dependence etc.

Bartweiss 9y ago

I've had a similar experience; a mild dose of oxycodone had no high, no withdrawal, and unremarkable pain relief. Individual variability is pretty high with opioids, both in efficacy and in metabolism speed. It's more pronounced with things like tramadol, but also true of oxycodone. At a guess, you might just be seeing much less impact from a given dose than other patients (and likely addicts might well be seeing more).

wastewaste 9y ago

because of renewed formular? I'm no pharmacist nor chemist, but my impression with drugs is that the popular names and actual composition are two different things. All they need is approval and if it helps relieve or avoid addiction I'm sure a minor change in, I don't know, isomery or adding a tiny functional extra tail to a big molecule doesn't preclude approval.

rjbwork 9y ago
It was generic Oxycodone. No name brand, no fancy time release, in both aforementioned cases. The first being in 2011.

xkcd-sucks 9y ago

Because addiction is an empirical behavioral phenomenon (you can't stop taking it and it makes your life worse) whereas tolerance+withdrawal are physical phenomena that correlate with, but are not, addiction. Current understanding is basically "addiction means not having your shit together," described in terms of predisposing factors such as stress, depression, physical dependence etc.