3 ms·
stupid question, but how do they got the mice with alzheimer's?
by justanotherjoe 9y ago
stupid question, but how do they got the mice with alzheimer's?
- SapphireSun 9y agoI don't know in detail, but suffice it to say that for many years we've had mouse strains with particular genetic alterations that appear to mimic Alzheimer's. Not my field, so google for more info.
- danieltillett 9y agoNot a stupid question at all. The answer is the mice are genetically engineered to overexpress beta-amaloid (or sometimes Tau).
- Someone 9y agoYou buy mice that are likely to develop it, for example at https://www.jax.org/mouse-search https://www.jax.org/mouse-search (I notice they offer a service to use CRISPR to design a mouse strain for you, too)
- xkcd-sucks 9y agoNot a stupid question. Mice (and all other animals besides maybe nonhuman primates) don't get Alzheimer's. There are mice bred to display symptoms of Alzheimer's. Because nobody knows the "root cause" it's a bit of a catch-22. The same holds true for many other neurodegenerative/psych disorders.