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The Open AI guys made a very impressive Dota 2 AI that trained itself through self play (and against pros), there is a pretty interesting write-up about it: ht

• Thorncorona 9y ago
  To shed some light on why they won, they chose a character (Shadow Fiend) that heavily relies on tight timings to execute moves. Naturally, AIs beat humans in events where timing is the key differentiator. Even so it’s quite impressive