4 ms·

But if the rate of clearage is the same then because I’m sleeping longer it should clear more of the protein?

by fnayr 9y ago

joveian 9y ago
I'm guessing there isn't enough research yet to say what effect your sleep pattern might have. It could be that concentration is important above some particular point and as long as you are getting sufficient regular sleep you keep it below that point. It sounds like there is also genetic variation in production, so if you have a generally lower production then a higher level due to your sleep pattern might still not be that high relative to others (or if you have higher than usual production then long days could be more likely to cause trouble). As someone with a circadian disorder, the thing I would worry about most from your sleep pattern is triggering a circadian disorder. At least Non-24 seems likely to have both a genetic predisposition and require triggering in many people (some have it from birth). This would be most likely if your normal rhythm seems to normally be longer than usual, although even there it isn't necessarily a problem since cave studes show people slip naturally into the type of sleep pattern that you describe. It might depend on how you do the transition (and how close you get to a two day cycle on your long days). But I would suggest at least being very observant of your circadian rhythm. Things like when you get hungry, feel tired, and have to pee can indicate how your circadian rhythm is doing and if those things change when you aren't staying up late then that could cause serious trouble eventually.
yorwba 9y ago
The amount of harmful protein cleared is likely proportional to the product of concentrations of the harmful protein and the clearing protein, because the two need to interact. That means that clearing becomes slower as less harmful protein is left. Prolonging the clearing process would mean that you spend a longer time at very low concentration, but not that the minimum concentration would be much lower. If the harm of high concentrations is disproportionally higher, the longer time at lower concentration would be unable to balance that out. However, this is only based on my rough intuition and I didn't even do any napkin math. If you want to really get a quantifiable comparison, you'd better find out about the concrete interactions in question and calculate it yourself. Or you could ask a physician who specializes in sleep (I forget what they are called), but if it isn't already published science somewhere, it's unlikely they could tell you anything other than that what you're doing is highly unusual and you should probably stop.
- fnayr 9y ago
  Thanks for the intuition. We're done very soon and hope to never go this hard again.

But if the rate of clearage is the same then because I’m sleeping longer it should clear more of the protein?

by fnayr 9y ago

But if the rate of clearage is the same then because I’m sleeping longer it should clear more of the protein?

I'm guessing there isn't enough research yet to say what effect your sleep pattern might have. It could be that concentration is important above some particular point and as long as you are getting sufficient regular sleep you keep it below that point. It sounds like there is also genetic variation in production, so if you have a generally lower production then a higher level due to your sleep pattern might still not be that high relative to others (or if you have higher than usual production then long days could be more likely to cause trouble). As someone with a circadian disorder, the thing I would worry about most from your sleep pattern is triggering a circadian disorder. At least Non-24 seems likely to have both a genetic predisposition and require triggering in many people (some have it from birth). This would be most likely if your normal rhythm seems to normally be longer than usual, although even there it isn't necessarily a problem since cave studes show people slip naturally into the type of sleep pattern that you describe. It might depend on how you do the transition (and how close you get to a two day cycle on your long days). But I would suggest at least being very observant of your circadian rhythm. Things like when you get hungry, feel tired, and have to pee can indicate how your circadian rhythm is doing and if those things change when you aren't staying up late then that could cause serious trouble eventually.

yorwba 9y ago

The amount of harmful protein cleared is likely proportional to the product of concentrations of the harmful protein and the clearing protein, because the two need to interact. That means that clearing becomes slower as less harmful protein is left. Prolonging the clearing process would mean that you spend a longer time at very low concentration, but not that the minimum concentration would be much lower. If the harm of high concentrations is disproportionally higher, the longer time at lower concentration would be unable to balance that out. However, this is only based on my rough intuition and I didn't even do any napkin math. If you want to really get a quantifiable comparison, you'd better find out about the concrete interactions in question and calculate it yourself. Or you could ask a physician who specializes in sleep (I forget what they are called), but if it isn't already published science somewhere, it's unlikely they could tell you anything other than that what you're doing is highly unusual and you should probably stop.

fnayr 9y ago
Thanks for the intuition. We're done very soon and hope to never go this hard again.