Personally I was quite impressed by what I had read about the "drugs for neglected diseases initiative" (DNDi). I recall seeing an interview where they mentione

Personally I was quite impressed by what I had read about the "drugs for neglected diseases initiative" (DNDi). I recall seeing an interview where they mentioned that trials are much easier conduct when the disease has very serious effects (i.e. death) and the existing treatments were poor since you needed far less statistical power to show that your treatment was better. I don't know how Sepsis fits into this, but they specifically do trials that drug companies won't.