Modern biologic immunomodulators have shown no benefit in survival in systemic inflammatory response syndrome. Steroids have not been assessed in SIRS specifica

Modern biologic immunomodulators have shown no benefit in survival in systemic inflammatory response syndrome. Steroids have not been assessed in SIRS specifically, though hey have been in sepsis and septic shock, where high dose steroids have been harmful and low dose steroids have been beneficial. It’s tough lobbing immunosuppressants at people with a rampant infection.