3 ms·
The Deisseroth lab has a materials list of the proteins utilized to do these neural optogenetic studies [1]. And if you want to play with those proteins yourse
by jfarlow 9y ago
The Deisseroth lab has a materials list of the proteins utilized to do these neural optogenetic studies [1].
And if you want to play with those proteins yourself or design your own, you can use our software to explore others' designs and modify them as you'd like [2]. (see specifically those proteins with "light sensitivity" like ChETA, AsLov, ArchT, Jaws, SwiChR, or ReaChR).
The optogenetic tools are very creative synthetic proteins using domains from within the human genome, as well as from many other sources to create light-sensitive ion channels and neural activity where there was none before.
Here's the mouse's brain being controlled by blue light by means of the synthetic ChR2 protein [3].
[1] https://web.stanford.edu/group/dlab/optogenetics/sequence_info.html https://web.stanford.edu/group/dlab/optogenetics/sequence_in...
[2] https://serotiny.bio/pinecone/ https://serotiny.bio/pinecone/
[3] https://www.youtube.com/watch?v=v7uRFVR9BPU https://www.youtube.com/watch?v=v7uRFVR9BPU