Zoho or Zimbra do a good job, I think. Plus will extend your non-gmail ajax-y world beyond just e-mail. I think a big problem with running your own server is t

Zoho or Zimbra do a good job, I think. Plus will extend your non-gmail ajax-y world beyond just e-mail. I think a big problem with running your own server is that things can go down! Yes, hosted solutions do too, but I think generally most serious providers have a bigger incentive for uptime than a personal box -- especially if that box is in my garage. I'd use my own machines for FTP and demos, but not for something like e-mail. (Or, if I did, I'd be sure to have a back-up redirect, where something else would forward the mail in and maintain survivability. I do this with my gmail anyway.)