5 ms·

Work on light-triggered genes overturns old assumptions about how memories form

55 points by nature24 9y ago

pests 9y ago
So basically previous thinking was that memory formation and recall used the same nueral circuit. This research shows that there is a heavy and slow write path and a secondary read path that is quick. This affects response time for memory recall. Reminds me of database design.
- JackFr 9y ago
  If your implicit model for the brain is that "it's a computer", it's moderately unsurprising when your results show computer like behavior. I think this is useful and groundbreaking research, but when articles use words like "neural circuit" it frustrates me. Circuit is a word with a specific meaning, and to talk about neural circuits seems to be projecting an implicit model that we don't really have justification for. Also the imprecision of the term "memory", in the sense of "this is where a memory is stored" seems also to overstate what is being measured, which is of course, behavior in response to stimuli. That is related to memory in the broad sense, but is it a memory? Is it even reasonable to think of memories as distinct and discrete things?
  - eref 9y ago
    The term "circuit" is used in neuroscience all of the place.
jfarlow 9y ago
The Deisseroth lab has a materials list of the proteins utilized to do these neural optogenetic studies [1]. And if you want to play with those proteins yourself or design your own, you can use our software to explore others' designs and modify them as you'd like [2]. (see specifically those proteins with "light sensitivity" like ChETA, AsLov, ArchT, Jaws, SwiChR, or ReaChR). The optogenetic tools are very creative synthetic proteins using domains from within the human genome, as well as from many other sources to create light-sensitive ion channels and neural activity where there was none before. Here's the mouse's brain being controlled by blue light by means of the synthetic ChR2 protein [3]. [1] https://web.stanford.edu/group/dlab/optogenetics/sequence_info.html https://web.stanford.edu/group/dlab/optogenetics/sequence_in... [2] https://serotiny.bio/pinecone/ https://serotiny.bio/pinecone/ [3] https://www.youtube.com/watch?v=v7uRFVR9BPU https://www.youtube.com/watch?v=v7uRFVR9BPU

55 points by nature24 9y ago

So basically previous thinking was that memory formation and recall used the same nueral circuit. This research shows that there is a heavy and slow write path and a secondary read path that is quick. This affects response time for memory recall. Reminds me of database design.

JackFr 9y ago
If your implicit model for the brain is that "it's a computer", it's moderately unsurprising when your results show computer like behavior. I think this is useful and groundbreaking research, but when articles use words like "neural circuit" it frustrates me. Circuit is a word with a specific meaning, and to talk about neural circuits seems to be projecting an implicit model that we don't really have justification for. Also the imprecision of the term "memory", in the sense of "this is where a memory is stored" seems also to overstate what is being measured, which is of course, behavior in response to stimuli. That is related to memory in the broad sense, but is it a memory? Is it even reasonable to think of memories as distinct and discrete things?
- eref 9y ago
  The term "circuit" is used in neuroscience all of the place.

jfarlow 9y ago

The Deisseroth lab has a materials list of the proteins utilized to do these neural optogenetic studies [1]. And if you want to play with those proteins yourself or design your own, you can use our software to explore others' designs and modify them as you'd like [2]. (see specifically those proteins with "light sensitivity" like ChETA, AsLov, ArchT, Jaws, SwiChR, or ReaChR). The optogenetic tools are very creative synthetic proteins using domains from within the human genome, as well as from many other sources to create light-sensitive ion channels and neural activity where there was none before. Here's the mouse's brain being controlled by blue light by means of the synthetic ChR2 protein [3]. [1] https://web.stanford.edu/group/dlab/optogenetics/sequence_info.html https://web.stanford.edu/group/dlab/optogenetics/sequence_in... [2] https://serotiny.bio/pinecone/ https://serotiny.bio/pinecone/ [3] https://www.youtube.com/watch?v=v7uRFVR9BPU https://www.youtube.com/watch?v=v7uRFVR9BPU