The downside is i) reproducibility. In the academic/research world there is a big move towards reproducible research, the nature of the Excel interface is not

The downside is i) reproducibility. In the academic/research world there is a big move towards reproducible research, the nature of the Excel interface is not conducive to that. A standard scripting language is fine that plays with Excel but you don't want Excel necessarily as the main access point and the menu driven approach isn't conducive to keeping a permanent record of what buttons you click on. ii) In multi-cultural settings Excel defaults to the users system language, these days you simply jsut work with students laptops rather than using a standardized lab, so unlss you are polyglot working with Excel is just a really bad idea. Jupyter provides a standard interface and the default is always English, but supports multilingual content. iii) Python modules provide a huge range of solutions for many different domain applications, it's hard to see how Excel as an interface would provide support for every one of these modules. What I mean is how would Excel work as an I/O interface to a Python script that was doing something other than working with data? Notebook solutions already do this quite well.