We actually have a pretty decent understanding regarding how the immune system remembers illnesses, although it is above my pay grade. if interested, read up o

We actually have a pretty decent understanding regarding how the immune system remembers illnesses, although it is above my pay grade. if interested, read up on "adaptive immune system" the genes involved in autoimmune disease are not as well understood as in some other diseases, and the individual contribution of any one gene is pretty small in autoimmune disease (compared to, say, spinal muscular atrophy). so as you say, a gene therapy approach might not be the right tool for the job. a lot of current approaches focus on "retraining" immune cells to be "good" rather than "bad" cells. here's a blog post about one of the leading startups in the space which was acquired by celgene, a large biotech company, for almost $800M earlier this year, just 3 months after raising their series a: https://lifescivc.com/2016/09/re-balancing-immunity-via-regulatory-t-cell-potentiation-introducing-delinia/ https://lifescivc.com/2016/09/re-balancing-immunity-via-regu...