4 ms·
Well I know without anyone reading or commenting on anything I link to I’ll be downvoted into oblivion for even trying to support conversations I’ve had with mu
by will_brown 9y ago
Well I know without anyone reading or commenting on anything I link to I’ll be downvoted into oblivion for even trying to support conversations I’ve had with multiple physicians, still as a physician yourself I ask you to at least weigh in on the following...is it not true that while genetic mutations can be the sole cause of disease that most disease are triggered by a combination of genetics and environmental factors (i.e. not the same as a protein dictating whether you have brown or blue eyes)? To my point re the microbiome google points to multiple studies including but not limited to:
> Here are just some of the health conditions that involve our microbes:
Acne
Antibiotic-associated diarrhea
Asthma/allergies
Autism
Autoimmune diseases
Cancer
Dental cavities
Depression and anxiety
Diabetes
Eczema
Gastric ulcers
Hardening of the arteries
Inflammatory bowel diseases
Malnutrition
Obesity
http://learn.genetics.utah.edu/content/microbiome/disease/ http://learn.genetics.utah.edu/content/microbiome/disease/
>Recent microbiome genome-wide association studies reveal that variants in many human genes involved in immunity and gut architecture are associated with an altered composition of the gut microbiome.
https://www.nature.com/articles/nrg.2017.63?WT.feed_name=subjects_immunology https://www.nature.com/articles/nrg.2017.63?WT.feed_name=sub...
>Researchers have discovered that a powerful guardian gene known to protect against a variety of autoimmune diseases, including type 1 diabetes, is triggered by the bacteria in our gut.
https://newatlas.com/guardian-gene-gut-bacteria-diabetes/51190/ https://newatlas.com/guardian-gene-gut-bacteria-diabetes/511...
- carbocation 9y agoWe can agree on many of the things that you wrote: - You need a combination of genetics + environment to have a phenotype (whether disease or otherwise) - Several conditions have a relationship with the gut microbiome Also, I think you will enjoy this absolutely amazing study that found that the gut microbiome drives cerebral cavernous malformations(!!!) by interactions with TLR4: https://www.nature.com/articles/nature22075 https://www.nature.com/articles/nature22075 So, I just don't think that "typically" the gut microbiome is the driver of disease. In fact, it's a rare enough find that people get Nature papers out of it. But, if it is actually typical, then I stand by my assertion that someone will eventually get a Nobel prize from proving it.