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Traditional variant calling, that is bayesian methods, have gotten very good at detecting point mutations, that is single letters. But have hit a wall when it c
by 8iterations 9y ago
Traditional variant calling, that is bayesian methods, have gotten very good at detecting point mutations, that is single letters. But have hit a wall when it comes to more complex structural mutations, we wanted to build this for example to focus on driver/passenger mutations in tumor/normal samples. (check out the "Preface" post for our LSTM version, and the logic behind this)