I've found that the mouse is the major culprit in any discomfort I might feel. I've cut down this discomfort to almost none by embracing keyboard shortcuts and

I've found that the mouse is the major culprit in any discomfort I might feel. I've cut down this discomfort to almost none by embracing keyboard shortcuts and accessibility options that only use the keyboard. This was actually easier on windows than it is on osx with the menu accelerators turned on, but I learn new tricks every week :) I almost forgot! Do not compromise on correct desk and chair height. I one had a CEO/owner who was neurotic about the neatness of the office and having several desks next to each other that were not adjusted to the same height seemed to her like it was sloppy and unprofessional. With people with a range of heights in the room, clearly one desk height does not fit all. It took a little time and some research, but after educating her on why personalized desk height is a necessity and not a luxury, she came around, even if it was grudgingly.