5 ms·

I haven't heard this about vitamin K before - please correct me if I'm wrong, but I don't think we know how the mechanism through which vitamin K reduces skelet

I haven't heard this about vitamin K before - please correct me if I'm wrong, but I don't think we know how the mechanism through which vitamin K reduces skeletal fractures.

AstralStorm 9y ago
Indeed we don't, plus the two forms of vitamin K (phylloquinone and menaquinone) have different mode of action. They are important cofactor for many proteins, including one called osteocalcin, needed for bone calcification.
- TheSpiceIsLife 9y ago
  It looks like Vitamin K also inhibits arterial calcification.[1] 1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052396/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052396/
hellofunk 9y ago
Correct; see my other comment as well. Vitamin K supplementation should not be casually added to anyone's diet without careful evaluation.
Matrixik 9y ago
Here you can find all info you want: https://examine.com/supplements/vitamin-k/ https://examine.com/supplements/vitamin-k/ Search on that page for: "Skeleton and Bone Metabolism". K1 and K2 work differently. We know a lot but there is still a lot more we don't know. Hell, looks like even different versions of K2 (from MK-4 to MK-13) works for different stuff in body. Only because MK-7 stays in blood for longer than MK-4 doesn't mean that it better. It could also mean that body is better in utilizing MK-4, or even that it's using it for different stuff. More here: https://chrismasterjohnphd.com/2016/12/03/start-here-for-vitamin-k2/ https://chrismasterjohnphd.com/2016/12/03/start-here-for-vit...
- seasonalgrit 9y ago
  Both of those sites appear to be money-making ventures that sell vitamins; I wouldn't consider them reliable sources. Here is a university page with information: http://www.umm.edu/health/medical/altmed/supplement/vitamin-k http://www.umm.edu/health/medical/altmed/supplement/vitamin-...
  - ConfucianNardin 9y ago
    Examine.com does NOT sell vitamins/supplements. They collect and analyze available research, and the result of that process is their product (in the form of guides etc).
    - seasonalgrit 9y ago
      Thanks for noting this. Their web site design (as well as the use of a dotcom domain) gives a misleading impression
      - Matrixik 9y ago
        And Chris Masterjohn, PhD is also working with them, example http://v6.examinecdn.com/erd/chrismasterjohn2.pdf http://v6.examinecdn.com/erd/chrismasterjohn2.pdf Personally I don't know better source with information about different supplements than examine.com, more how they are working here: https://examine.com/about/ https://examine.com/about/ If you know better source point it to me, please. This university page you provided is short and old. Just one question: what's wrong with using dotcom domain?
        seasonalgrit 9y ago
        If examine.com's metaanalsyses are based on legitimate research papers -- and you've read some of the papers yourself and find that they indeed provide support for the article citing them -- then i'd say yeah, use the site. i guess to respond to your question: most biomedical research today is eminating from universities and university-affiliated entites. page for page, i generally wouldn't expect a .com web site -- the majority of which are probably just attempting to generate advertising revenue -- to be on par in terms of accuracy etc with a .edu site. generally, I've found one of the best ways to improve the signal-to-noise ratio is to filter to a specific set of domains (e.g., ,edu, .gov) when searching online.

I haven't heard this about vitamin K before - please correct me if I'm wrong, but I don't think we know how the mechanism through which vitamin K reduces skeletal fractures.

AstralStorm 9y ago

Indeed we don't, plus the two forms of vitamin K (phylloquinone and menaquinone) have different mode of action. They are important cofactor for many proteins, including one called osteocalcin, needed for bone calcification.

TheSpiceIsLife 9y ago
It looks like Vitamin K also inhibits arterial calcification.[1] 1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052396/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052396/

hellofunk 9y ago

Correct; see my other comment as well. Vitamin K supplementation should not be casually added to anyone's diet without careful evaluation.

Matrixik 9y ago

Here you can find all info you want: https://examine.com/supplements/vitamin-k/ https://examine.com/supplements/vitamin-k/ Search on that page for: "Skeleton and Bone Metabolism". K1 and K2 work differently. We know a lot but there is still a lot more we don't know. Hell, looks like even different versions of K2 (from MK-4 to MK-13) works for different stuff in body. Only because MK-7 stays in blood for longer than MK-4 doesn't mean that it better. It could also mean that body is better in utilizing MK-4, or even that it's using it for different stuff. More here: https://chrismasterjohnphd.com/2016/12/03/start-here-for-vitamin-k2/ https://chrismasterjohnphd.com/2016/12/03/start-here-for-vit...

seasonalgrit 9y ago
Both of those sites appear to be money-making ventures that sell vitamins; I wouldn't consider them reliable sources. Here is a university page with information: http://www.umm.edu/health/medical/altmed/supplement/vitamin-k http://www.umm.edu/health/medical/altmed/supplement/vitamin-...
- ConfucianNardin 9y ago
  Examine.com does NOT sell vitamins/supplements. They collect and analyze available research, and the result of that process is their product (in the form of guides etc).
  - seasonalgrit 9y ago
    Thanks for noting this. Their web site design (as well as the use of a dotcom domain) gives a misleading impression
    - Matrixik 9y ago
      And Chris Masterjohn, PhD is also working with them, example http://v6.examinecdn.com/erd/chrismasterjohn2.pdf http://v6.examinecdn.com/erd/chrismasterjohn2.pdf Personally I don't know better source with information about different supplements than examine.com, more how they are working here: https://examine.com/about/ https://examine.com/about/ If you know better source point it to me, please. This university page you provided is short and old. Just one question: what's wrong with using dotcom domain?
      - seasonalgrit 9y ago
        If examine.com's metaanalsyses are based on legitimate research papers -- and you've read some of the papers yourself and find that they indeed provide support for the article citing them -- then i'd say yeah, use the site. i guess to respond to your question: most biomedical research today is eminating from universities and university-affiliated entites. page for page, i generally wouldn't expect a .com web site -- the majority of which are probably just attempting to generate advertising revenue -- to be on par in terms of accuracy etc with a .edu site. generally, I've found one of the best ways to improve the signal-to-noise ratio is to filter to a specific set of domains (e.g., ,edu, .gov) when searching online.