At this point in time for me, having worked with a couple of Python web frameworks, I would recommend Django hands-down every time. For me it comes down to one

At this point in time for me, having worked with a couple of Python web frameworks, I would recommend Django hands-down every time. For me it comes down to one simple thing though: Migrations Django has, far and away, the best migrations system I've used in a Python framework (although I won't claim to have used them all). Compared to Alembic it's vastly superior also beats most jerry-rigged solutions.