The articles point is that we've actually made a lot of progress in treating chronic illnesses versus where we were decades ago with the discovery of statins, b

The articles point is that we've actually made a lot of progress in treating chronic illnesses versus where we were decades ago with the discovery of statins, beta blockers, aces / arbs, metformin, insulin etc. this is "low hanging fruit". The next generation of drugs for chronic illness face a higher bar than the previous generation of drugs: they can't just work better than placebo, they must work better than a drug that works. And while we've identified many many molecules associated with diseases, only a very small portion of these are amenable to targeting with current drug tech. These have been picked over fairly well. A new generation of drugs will need a breakthrough like "fracking" in oil to create more novel drugs I'd disagree that there are very few cases where the body's response is inappropriate. Arguably in every diseases this is the case. We have identified some instances of this but not as many as we'd like, and in many cases even if we've identified instances we can't do anthying about them