If your website is more like an application, think of gmail, then a framework like cappuccino (http://cappuccino.org/ http://cappuccino.org/) come with pretty g

If your website is more like an application, think of gmail, then a framework like cappuccino (http://cappuccino.org/ http://cappuccino.org/) come with pretty good design defaults. And no css/photoshop skills required. It will require learning obctive-j and a couple of cocoa though.