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Are you familiar with c diff? Placebo's don't work. It's dangerous to have placebo controlled trials with this disease. The current standard of care is a course
by rm2889 9y ago
Are you familiar with c diff? Placebo's don't work. It's dangerous to have placebo controlled trials with this disease. The current standard of care is a course of very strong antibiotics which still leave > 25% chance of recurrence. These antibiotics are most often used as a control group in c diff infections.
In general, placebo controlled trials are usually conducted for diseases which don't have an effective standard of care, or for conditions which aren't serious enough to be considered life threatening. For more serious diseases where a standard of care exists (standard of care is usually scientifically discovered but validated by placebo controlled trials), you conduct trials and compare the performance of the new drug/therapy with the existing standard of care as the control group.
- TheAdamAndChe 9y agoYup. It's like wanting placebo controlled trials for cancer. It would be unethical and ungodly harmful to condemn people to suffering and death just so people could gather data that wouldn't even compare the results to the current best practices.
- IanCal 9y agoAlso the result you care about is often not "does it work?" but "does it work better than the current approach?".
- cpncrunch 9y ago>Are you familiar with c diff? Placebo's don't work More familiar than you apparently, because placebos have been proven to work: https://www.medscape.com/viewarticle/853175 https://www.medscape.com/viewarticle/853175 I think the problem is the subjective measure, so it's impossible to know which symptoms are caused by c.diff and which from IBS.