Would I need experience working with large scale systems to have a chance? My web experience is mostly in small startups for SaaS, and web agencies that build e

Would I need experience working with large scale systems to have a chance? My web experience is mostly in small startups for SaaS, and web agencies that build e-commerce sites and blogs for small-medium businesses. I have not worked on anything that gets used by the millions, or requires fine calculations. Will I be at a disadvantage?