This is a candidate-gene study: a single gene in a single population without replication. Previous candidate-gene studies on other traits have replication rates

This is a candidate-gene study: a single gene in a single population without replication. Previous candidate-gene studies on other traits have replication rates as low or lower than 1% despite apparently dramatic effect sizes - GWASes they definitely are not! I'll believe this mutation when I see it replicated somewhere else.