It took about two weeks of daily use. I switched my mouse at work to be left handed and committed myself to not switching back if I got frustrated. Before I k

It took about two weeks of daily use. I switched my mouse at work to be left handed and committed myself to not switching back if I got frustrated. Before I knew it, it felt as natural as my other hand, and I can go back and forth with ease. I'd actually say that off-hand mousing is now my preferred state. It helped that at the time I was doing a lot of work in Adobe Illustrator so I was really getting a lot of fine-control practice. You might try playing a game like Minesweeper for a similar effect.