When organs are transplanted today they were formed from DNA that was not your own, so it would not surprise me if there is some physiological reason that might

When organs are transplanted today they were formed from DNA that was not your own, so it would not surprise me if there is some physiological reason that might explain why people feel that way. When I mention recreating a replica I don't just mean the appearance. An ideal exact replica would be an exact cellular recreation of the original organ or appendage. If we did achieve such technical abilities I'm not sure how anyone would be able to discern any difference. The only possible explanation I can see would be the simple knowledge that something had been replaced. (Kind of coming back to this being a perception that people hold in their head) Absent such knowledge, I doubt anyone would be able to discern that they are in fact not themselves.