Well, I'd be careful in saying that booze:liver as THC:brain. They both act on the brain and both have a neurological basis for tolerance. An alcoholic's liver

Well, I'd be careful in saying that booze:liver as THC:brain. They both act on the brain and both have a neurological basis for tolerance. An alcoholic's liver will up regulate enzymes to speed the metabolism of alcohol, but their brain chemistry will also change just as a weed-smoker's. Just as smokers up regulate cannabinoid receptors, alcoholics up regulate GABA (both among others). When alcoholics go through withdrawal, they can die of seizures caused by their brain having too many GABA receptors to properly function without the presence of alcohol.