This is the calculus that you need to make in business travel, even at startups. You're flying out your CEO on a business deal to Asia, on a 10 hour flight. You

This is the calculus that you need to make in business travel, even at startups. You're flying out your CEO on a business deal to Asia, on a 10 hour flight. You can save $3k by flying him/her on Economy, but what is the hidden cost to the business by having him/her be a zombie for the next 48 hours while he/she has to negotiate a deal?