5 ms·
It's interesting to note that tetrahydrocannabinol and other compounds found in marijuana may reduce the amount of beta amyloid in the brain. Beta amyloid is co
by _Marak_ 9y ago
It's interesting to note that tetrahydrocannabinol and other compounds found in marijuana may reduce the amount of beta amyloid in the brain. Beta amyloid is commonly thought to cause Alzheimer's disease.
see: https://www.nature.com/articles/npjamd201612 https://www.nature.com/articles/npjamd201612
Last I heard in the US, the Federal government was still making it difficult to run clinical trials for Alzheimer's using marijuana. I think any federally funded medical trial using marijuana needs to be approved by the DEA.
- Beltiras 9y agoIt's more complex than just that. At CTAD just a couple of weeks ago there was a presentation on drugs that managed to reduce AB (biomarker was inferred by a PET scan) and it did not result in increased cognition.
- SirensOfTitan 9y agoCould it be that the presence of beta amyloids already caused structural changes to the brain? I know nothing about Alzheimer's.
- eganist 9y agoA simple hypothesis which could explain this might be that the plaques cause effectivelt permanent brain damage. The question is whether degenerative patterns ceased or slowed after substantial clearing of plaques from the brain. I would expect this test (and therefore the hypothesis) to fail if the plaques themselves are a byproduct rather than the cause of degradation in brain function. That said, I'm surprised I haven't read much in Gates' Notes or other funding sources on potential ties to HSV1 considering all the increasingly supportive research between the two.
- JamesBarney 9y agoThey used several techniques that clear beta amyloid from the brain.(antibodies and ultrasound). And they've have little if any effect on cognition. I'm starting to think beta amyloid is a red herring, or maybe just important in the prodromal stages of the disease.
- reasonattlm 9y agoAnother point is that a majority of Alzheimer's patients have other neurodegenerative conditions, with vascular dementia being one of the most common. So it is reasonable to expect that you can in fact meaningfully address Alzheimer's and see little to no improvement in a patient.
- jonwachob91 9y ago> (biomarker was a PET scan) A PET scan is not a biomarker. The Amyloid Beta (AB)* is the biomarker, the PET w/ tracer (such as the Pittsburg Compound Beta) are used to detected the biomarker. It's also important to note that Amyloid Beta is only part of the problem. Neurofibrillary Tangles (NFT) are the primary biomarker of Alzheimer's Dementia, and happen inside the neurons. NFTs disable to ability for neurons to communicate with each other, and lead to the death of disabled neurons. It is completely possible that we can't reverse AD, but can only slow it down / halt progression. *Was it AB40 / AB42 / or a different Amyloid Beta?
- Beltiras 9y agoI'll edit for clarity, was inferred by was my thinking. I only had a second hand presentation this morning by an attendee.