3 ms·
No mention of CYP1A2 genotype which affects caffeine metabolism rate. From a different study (2006): Intake of coffee was associated with an increased risk of
by js2 9y ago
No mention of CYP1A2 genotype which affects caffeine metabolism rate. From a different study (2006):
Intake of coffee was associated with an increased risk of nonfatal MI only among individuals with slow caffeine metabolism, suggesting that caffeine plays a role in this association. ... The purpose of this study was to determine whether CYP1A2 genotype modifies the association between intake of caffeinated coffee and risk of nonfatal MI.
https://jamanetwork.com/journals/jama/fullarticle/202502 https://jamanetwork.com/journals/jama/fullarticle/202502
A more recent (2015) report has this conclusion w/r/t CVD:
Consistent observational evidence indicates that moderate coffee consumption is associated with reduced risk of type 2 diabetes and cardiovascular disease in healthy adults. In addition, consistent observational evidence indicates that regular consumption of coffee is associated with reduced risk of cancer of the liver and endometrium, and slightly inverse or null associations are observed for other cancer sites.
https://health.gov/dietaryguidelines/2015-scientific-report/14-appendix-e2/e2-39a.asp https://health.gov/dietaryguidelines/2015-scientific-report/...
This NYT article summarizes and links to a bunch of studies:
https://well.blogs.nytimes.com/2016/07/12/for-coffee-drinkers-the-buzz-may-be-in-your-genes/ https://well.blogs.nytimes.com/2016/07/12/for-coffee-drinker...
BTW, if you've used 23andme, it should have your CYP1A2 genotype.
- steadicat 9y agoI have 23andme, but their results are not very clear. All they say is “You have two variants associated with consuming more caffeine.” I’m unsure how to square that with the studies above. Do I have fast or slow metabolism? Do I have higher or lower risk of MI?
- js2 9y agoLooks like they revised how they present the data. Try looking in the archived reports in the drug response section. It should categorize you as a fast or slow metabolizer. You can probably figure this out also from the raw data but I can’t give you any guidance there. https://you.23andme.com/reports/report_archive/download/report_archive_summary/ https://you.23andme.com/reports/report_archive/download/repo...
- kyberias 9y agoFigure out what is the name of the SNP of the CYP1A2 variant, download your SNP data from 23andme and look for it yourself.
- kyberias 9y agoActually I can help you out some more. The SNP in question is rs762551. Go to Tools -> Browse RAW data -> search for rs762551. It should show something like this: Gene SNP genomic loc Variants Your result CYP1A2 rs762551 75041917 A or C ? / ? If you have A/A you're "fast metabolizer". (good) If you have A/C or C/C, you're "slow metabolizer". (not so good) From SNPedia: "In terms of genotypes, only rs762551(A;A) individuals are considered fast metabolizers. Individuals who are rs762551(A;C) heterozygotes or rs762551(C;C) homozygotes are both considered slow metabolizers."