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I've been out of the field for a while, but I see a similarity between the old BAC vs. shotgun and newer SNP vs. full-sequence debate. While my academic friends
by c1sc0 16y ago
I've been out of the field for a while, but I see a similarity between the old BAC vs. shotgun and newer SNP vs. full-sequence debate. While my academic friends scoff at SNP-based products like the ones commercialized by 23andme, I believe there is value in going for reach vs. depth. You can draw a similarity here with coding: running up technical debt is fine in the short term as long as you are sure someone will come in later and clean up the mess.