Maybe I'm missing something, but frankly I think if you're building GUI with Python, tkinter is probably the best option. Comes with stock, is pretty solid, and

Maybe I'm missing something, but frankly I think if you're building GUI with Python, tkinter is probably the best option. Comes with stock, is pretty solid, and on edge-cases serves you well. I had to create some applications with py earlier this year, I started out with pyside but it was really heavy and kind of difficult to grok. wxwidgets I tried as well and it didn't work (I needed mouse cursor information and use it in a certain way to draw certain things, it was messy to do it with everything except tkinter).