Acetaminophen and ibuprofen are safe and effective together. The label you refer to advises against using other medicines that contain acetaminophen, as many c

Acetaminophen and ibuprofen are safe and effective together. The label you refer to advises against using other medicines that contain acetaminophen, as many cold and allergy medicines do (Excedrin, NyQuil, Robitussin). The thing you want to look out for are not doubling up acetaminophen, and not taking any combination of aspirin + naproxen + ibuprofen.