4 ms·
Here are the links to the study (missing from the Scientific American article but in the original): - Gut microbiome modulates response to anti–PD-1 immunothe
by boyd 9y ago
Here are the links to the study (missing from the Scientific American article but in the original):
-
Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients http://science.sciencemag.org/content/early/2017/11/01/science.aan4236.full http://science.sciencemag.org/content/early/2017/11/01/scien...
- Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors http://science.sciencemag.org/content/early/2017/11/01/science.aan3706.full http://science.sciencemag.org/content/early/2017/11/01/scien...
Here is some earlier (cited) work in mice that very strongly showed an effect between this therapy and the mouse gut microbiome (Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy): http://science.sciencemag.org/content/early/2015/11/04/science.aac4255.full http://science.sciencemag.org/content/early/2015/11/04/scien.... Really interesting to see these finding preliminarily reproduced in a clinical setting.
- AlexCoventry 9y agoDo you have the DOIs for the supplementary materials available?