A better argument against this line of development is that it is demonstrably expensive and low-yield. There are far better R&D approaches to maintaining healt

A better argument against this line of development is that it is demonstrably expensive and low-yield. There are far better R&D approaches to maintaining health over the course of aging, but they get a tiny fraction of the effort lavished on exercise and calorie restriction mimetics, despite the continued absence of concrete therapeutic outcomes resulting from all of that investment. The reason for this is probably that exercise and calorie restriction mimetic research dovetails well with the real underlying scientific goal of mapping metabolism, where as better approaches tend to bypass this need for mapping, focusing instead on well-known forms of damage that cause age-related decline.