Several people have mentioned Flask. Eve is a well-written and actively-developed Flask framework for building RESTful API services: http://python-eve.org http

Several people have mentioned Flask. Eve is a well-written and actively-developed Flask framework for building RESTful API services: http://python-eve.org http://python-eve.org. It's most at home with a MongoDB backend but can also use SQL RDBMS, ElasticSearch and Neo4J.