I don't know for aspirin but the method of intake may not matter: e.g. non steroidal anti-inflammatory drugs such as ketoprofen induce aggression of the gastroi

I don't know for aspirin but the method of intake may not matter: e.g. non steroidal anti-inflammatory drugs such as ketoprofen induce aggression of the gastrointestinal system in ways unrelated to ingestion, hence why on the short run you're encouraged to eat (which will somehow dilute the natural gastric acid) right after having taking the medication (which takes ~0.5hrs to reach peak blood concentration[1]but falls gradually afterwards), or on the long run you may be encouraged to take proton pump[0] inhibitors, which come with their own side effects. (Disclaimer: not a medic, only remotely a chemist, but had to deal with this for extended durations). It's an awfully complex equation of chemical actions and risks vs benefits. Be safe, nothing about this is magic and can have serious consequences. [0]: https://en.wikipedia.org/wiki/Proton_pump#In_humans https://en.wikipedia.org/wiki/Proton_pump#In_humans [1]: four doses of ketoprofen: https://www.drugs.com/pro/images/c2c99853-1268-4998-a44b-2bf0c0b70fd2/image-02.jpg https://www.drugs.com/pro/images/c2c99853-1268-4998-a44b-2bf... (from https://www.drugs.com/pro/ketoprofen.html https://www.drugs.com/pro/ketoprofen.html)