3 ms·
There are meta-analyses of the RCTs for baby aspirin which also indicate reductions in all-cause mortality probably through its effect on cancer rates. I'd cons
by gwern 9y ago
There are meta-analyses of the RCTs for baby aspirin which also indicate reductions in all-cause mortality probably through its effect on cancer rates. I'd consider them much more important than this result which is ultimately just another correlational/observational result. Some of the studies I'm thinking of:
- Rothwell et al 2012 "Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials" http://www.istudymedicine.com/wp-content/uploads/aspirin.pdf http://www.istudymedicine.com/wp-content/uploads/aspirin.pdf
- "Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials" http://www.beppegrillo.it/immagini/Aspirin%20and%20death%20from%20cancer%20(Lancet%202010).pdf http://www.beppegrillo.it/immagini/Aspirin%20and%20death%20f...
- "Aspirin for prophylactic use in the primary prevention of cardiovascular disease and cancer: a systematic review and overview of reviews" https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0083409/ https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0083409/ , Sutcliffe et al 2013
- Pignone et al 2013, "Effect of including cancer mortality on the cost-effectiveness of aspirin for primary prevention in men" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797356/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797356/
- "Estimates of benefits and harms of prophylactic use of aspirin in the general population", Cuzick et al 2014 http://annonc.oxfordjournals.org/content/26/1/47.full http://annonc.oxfordjournals.org/content/26/1/47.full
- Cuzick et al 2015, [Estimates of benefits and harms of prophylactic use of aspirin in the general population" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269341/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269341/)