3 ms·
But wait, there's more! There are at least two COX pathways; COX-1 is involved in protection of stomach lining, COX-2 is responsible, in part, for pain signalli
by nnfy 9y ago
But wait, there's more! There are at least two COX pathways; COX-1 is involved in protection of stomach lining, COX-2 is responsible, in part, for pain signalling.
Aspirin inhibits both pathways. Other NSAIDs do the same, although they typically have less of an effect on COX-1.
There is something on the unnoficial market which may inhibit only COX-2, a sort of holy grail in the last few decades of medicine: kratom[0].
0.https://www.ncbi.nlm.nih.gov/pubmed/21513785 https://www.ncbi.nlm.nih.gov/pubmed/21513785
- idclip 9y agoDamnit im trying to finish a project! Now i have to read that link :P
- jessriedel 9y agoRight, there is some evidence that COX-2 selective inhibitors may be safer for patients with inflammatory bowel disease like Crohn's and Ulcerative Colitis. Currently, those patients are generally advised to not take an NSAIDs. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034022/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034022/
- jaggederest 9y agoAh, but interestingly, inhibiting either cox pathway independently doesn't damage mucosa. you have to inhibit both, simultaneously, and the limiting factor is the one that is the least inhibited. So it's not just "COX-2 good, COX-1 bad", it's actually "Either pathway is fine to inhibit selectively as long as you don't inhibit both"
- ac29 9y agoAnecdotally, Kratom use can also lead to long, opiate like withdrawls (weeks of hyperalgesia, no fun). Other short term opiate like side effects like nausea are common as well. I would definitely recommend against self-experimentation unless you are prepared for lengthy withdrawl symptoms. Hopefully more research can be done into its constituent chemicals before it is banned in the US. The DEA already tried, and its illegal in several states.