4 ms·

Took me a while to find, but this method apparently only increases the life span of mice by 25%. Given how mice are prey animals - i.e. they aren't meant to liv

Took me a while to find, but this method apparently only increases the life span of mice by 25%. Given how mice are prey animals - i.e. they aren't meant to live long - I don't anticipate the same results with Humans. Although, it may help reduce risks of diseases. It'll be interesting to see results.

BurningFrog 9y ago
I'll take an "only" 20 year life span increase.
- leggomylibro 9y ago
  "I plan to live forever, of course, but barring that I'd settle for a couple thousand years. Even five hundred would be pretty nice." — CEO Nwabudike Morgan, Alpha Centauri
- SubiculumCode 9y ago
  Hell I'd take the normal span with my health and my mind intact. I've seen old brains. It scares me.
  - andai 9y ago
    Yeah, I wonder if senolytics have a positive effect on the brain.
    - mcbits 9y ago
      We already have a potential treatment for age-related cognitive decline: vampirism (kinda). https://www.scientificamerican.com/article/fountain-of-youth-young-blood-infusions-ldquo-rejuvenate-rdquo-old-mice/ https://www.scientificamerican.com/article/fountain-of-youth...
- sillysaurus3 9y ago
  Their point is that the lifespan increase is probably unique to mice. Mice are designed to die quickly.
  - SubiculumCode 9y ago
    So are we. You think 80 some odd years is a long time?
    - sillysaurus3 9y ago
      Most animals die sooner.
    - DaiPlusPlus 9y ago
      80 years is too short. That's only 20 American presidential terms.
- JoshTriplett 9y ago
  I'll take a 20 year lifespan increase at least every 20 years. Preferably a 20 year lifespan increase every 5-15, for a healthy safety margin.
diggernet 9y ago
Even if there is 0% increase in median lifespan, they describe many effects which would make aging a much less miserable and debilitating experience. That alone is a win. Take this bit: "can restore lustrous hair and physical fitness to ageing mice" Think of it! Finally, a cure for baldness! And, yeah, less of a decline in fitness would be nice, too.
- return0 9y ago
  it just means bald with shiny hair.
  - ryuker16 9y ago
    Organs improved too
- Retric 9y ago
  It does provide an interesting model why ~80 is considered an average lifespan, but some people can live up to ~120 and be unusually heathy at 80/90 etc.
stevenwoo 9y ago
I thought a huge part of the problem is mice are not that similar to humans (lots of things have different effects on mice versus humans) but mice are really easy/cheap to test with compared to larger mammals that are a bit closer to humans. We could be missing a lot by not testing stuff in humans that has zero/deleterious effect in mice.
deleted 9y ago
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BurningFrog 9y ago

I'll take an "only" 20 year life span increase.

leggomylibro 9y ago
"I plan to live forever, of course, but barring that I'd settle for a couple thousand years. Even five hundred would be pretty nice." — CEO Nwabudike Morgan, Alpha Centauri
SubiculumCode 9y ago
Hell I'd take the normal span with my health and my mind intact. I've seen old brains. It scares me.
- andai 9y ago
  Yeah, I wonder if senolytics have a positive effect on the brain.
  - mcbits 9y ago
    We already have a potential treatment for age-related cognitive decline: vampirism (kinda). https://www.scientificamerican.com/article/fountain-of-youth-young-blood-infusions-ldquo-rejuvenate-rdquo-old-mice/ https://www.scientificamerican.com/article/fountain-of-youth...
sillysaurus3 9y ago
Their point is that the lifespan increase is probably unique to mice. Mice are designed to die quickly.
- SubiculumCode 9y ago
  So are we. You think 80 some odd years is a long time?
  - sillysaurus3 9y ago
    Most animals die sooner.
  - DaiPlusPlus 9y ago
    80 years is too short. That's only 20 American presidential terms.
JoshTriplett 9y ago
I'll take a 20 year lifespan increase at least every 20 years. Preferably a 20 year lifespan increase every 5-15, for a healthy safety margin.

diggernet 9y ago

Even if there is 0% increase in median lifespan, they describe many effects which would make aging a much less miserable and debilitating experience. That alone is a win. Take this bit: "can restore lustrous hair and physical fitness to ageing mice" Think of it! Finally, a cure for baldness! And, yeah, less of a decline in fitness would be nice, too.

return0 9y ago
it just means bald with shiny hair.
- ryuker16 9y ago
  Organs improved too
Retric 9y ago
It does provide an interesting model why ~80 is considered an average lifespan, but some people can live up to ~120 and be unusually heathy at 80/90 etc.

stevenwoo 9y ago

I thought a huge part of the problem is mice are not that similar to humans (lots of things have different effects on mice versus humans) but mice are really easy/cheap to test with compared to larger mammals that are a bit closer to humans. We could be missing a lot by not testing stuff in humans that has zero/deleterious effect in mice.

deleted 9y ago

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